Strong Medicine

Dr. Lu Delgado is running out of money to run her free clinic by herself. When Lu goes to prestigious Rittenhouse Hospital to ask for assistance, famous O.B.G.Y.N./surgeon Dr. Dana Stowe blames Lu for ruining her breast cancer study to find a cure for cancer after Lu tells a woman her opinon about test studies. Dana later is asked by Chief of Staff Dr. Bob Jackson to tour Lu's clinic and see if the clinic should get funded by Rittenhouse . Dana tells one of her patients that she has ovarian cancer and that she will not be able to have any children even though she has the desire to. In the end, Dr. Lydia Emerson comes up with the perfect solution to Lu's problem.

The second season begins with Dana and Lu at odds over the fate of a dead college student's fertilized eggs. The day is further complicated by the arrival of Peter's mother, who clings to the idea that her heterosexual son is gay. Elsewhere, a dying patient and her husband wait impatiently for a donor heart and Nick's appointment to the ER staff is in doubt.

As Dana's upcoming birthday makes her decide to seek a volunteer sperm donor so that she can have a child, she is confronted with a newborn who is HIV-positive. Lu is accused by an enraged mother of being responsible for her teenage daughter's sexually-transmitted disease because Lu provided the girl with birth control.

In a surprise twist following the suspenseful season finale cliffhanger, Mickey jumped in front of Lu and took the bullet for her; saving her life. Lu quickly rushes him to the hospital but little can be done to save his life besides putting him on a respiratory machine. Andy and Bob try to convince Lu to take him off the respirator. While Lu deals with the emotional trauma of Mickey's death, Andy tries to perform an experimental procedure on a baby in a bubble but is interrupted by Bob with news that the FDA has un-approved the procedure. Meanwhile Andy gets herself into a bureaucritical battle when she tries to get a patient who has no health insurance a free heart transplant. Also, Andy must tell Lizzy and Jesse that she and Les are getting a divorce and that he is moving across the country.

Nick is transferred to Manhatten General. Ben's HIV test has a positive result. Also, Ben hires his ex-wife to make up for the damage he caused to her career. Andy learns that her daughter Jesse's friend is addicted to cough syrup. Kayla Thorton, a new intern, is pushed into the hustle and bustle of the ER. She gets into trouble when she asks a girl if she is sexually active in front of her mother and things go terribly wrong. Jesse gives her friend CPR to save her life after she loses consciousness due to consuming too much syrup. Andy feels responsible for the incident because Jesse's friend was in her care.

Lu meets Andy 's replacement, Dr. Dylan West, an obnoxious man she worked with when she was an intern as they struggle to save the lives of the many people involved in a train accident. Later, she discovers something shocking while talking to a bipolar patient. The president is in town and the Secret Service makes sure the hospital keeps plenty of B- blood (the president's rare blood type) on hand. Dylan tries to help a pregnant patient make the right decision about a potentially hazardous surgery. Meanwhile, Lu contemplates marrying Jonas while dealing with the obnoxious woman who caused Dr. Jackson to lose his job. Later, the unthinkable happens to Lu and she and those close to her struggle to save her life.